Acetic Acid → Tert-butyl 3-(ethylamino)pyrrolidine-1-carboxylate

HRID 2345559Notes

Reaction equation

HRID 2345559 reaction equation
[C:4]([BH3-:5])#[N:6].[CH3:30][OH:31].[CH3:8][C:9](=[O:10])[OH:11].[CH:1]([CH3:2])=[O:3].[NH2:12][CH:13]1[CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]1.[Na+:25].[Na+:7].[OH:26][C:27](=[O:28])[O-:29]>>[CH2:1]([CH3:2])[NH:12][CH:13]1[CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 177AcetaldehydeHCID 769Bicarbonate IonHCID 887MethanolHCID 923Sodium ion2×HCID 498716Cyano-borohydrideHCID 27563701-Boc-3-aminopyrrolidine

Product 1

HCID 20800658Tert-butyl 3-(ethylamino)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-485e43c536f24e3fabcdd172fb1ee721
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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