反应详情

To a solution of 22.0 g (108 mM) of undecanoyl chloride in 185 ml of pyridine, 22.2 g (110 mM) of 4-methoxyphenacylamine hydrochloride was gradually added in 30 minutes under cooling and stirring below -5° C., followed by stirring for 30 minutes below -5° C. and heat-refluxing of 1 hour under stirring. After the reaction, the reaction mixture was cooled to room temperature and poured into 1 liter of cool water to precipitate a crystal. The crystal was recovered by filtration, washed with water and recrystallized from ethanol to obtain 13.9 g of decanoyl-4-methoxyphenacylamine (Yield: 38.8%).

1. temperatureunder cooling
2. stirringby stirring for 30 minutes below -5° C.
3. temperatureheat-refluxing of 1 hour
4. stirringunder stirring
5. customAfter the reaction
6. customto precipitate a crystal
7. filtrationThe crystal was recovered by filtration
8. washwashed with water
9. customrecrystallized from ethanol