(2-Bromoethoxy)-tert-butyldimethylsilane → 5-Chloro-thiophene-2-carboxylic acid {2-[[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-(1-isopropyl-piperidin-4-yl)-sulfamoyl]-ethyl}-amide

HRID 2346181Notes

Reaction equation

HRID 2346181 reaction equation
[Br:1][CH2:2][CH2:3][O:4][Si:5]([CH3:6])([CH3:7])[C:8]([CH3:9])([CH3:10])[CH3:11].[CH:12]([CH3:13])([CH3:14])[N:15]1[CH2:16][CH2:17][CH:18]([NH:21][S:22](=[O:23])(=[O:24])[CH2:25][CH2:26][NH:27][C:28](=[O:29])[c:30]2[s:31][c:32]([Cl:35])[cH:33][cH:34]2)[CH2:19][CH2:20]1>>[CH2:2]([CH2:3][O:4][Si:5]([CH3:6])([CH3:7])[C:8]([CH3:9])([CH3:10])[CH3:11])[N:21]([CH:18]1[CH2:17][CH2:16][N:15]([CH:12]([CH3:13])[CH3:14])[CH2:20][CH2:19]1)[S:22](=[O:23])(=[O:24])[CH2:25][CH2:26][NH:27][C:28](=[O:29])[c:30]1[s:31][c:32]([Cl:35])[cH:33][cH:34]1

Participants

3

Reactant 2

HCID 3608067(2-Bromoethoxy)-tert-butyldimethylsilaneHCID 119904785-Chloro-Thiophene-2-Carboxylic Acid [2-(1--Isopropyl-Piperidin-4-Ylsulfamoyl)-Ethyl]-Amide

Product 1

HCID 666246175-Chloro-thiophene-2-carboxylic acid {2-[[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-(1-isopropyl-piperidin-4-yl)-sulfamoyl]-ethyl}-amide

Sources & evidence

ORD record
ord-7231db06d41f4feba4106f19481346c9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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