2-Chlorobenzyl chloride → HCID 178505747, compound

HRID 234629Notes

Reaction equation

HRID 234629 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][CH2:12][C@H:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23]Cl>>[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][N:17]1[CH2:16][CH2:15][N:14]([C@H:11]2[CH2:10][CH2:9][C@H:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[CH2:13][CH2:12]2)[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 119062-Chlorobenzyl chlorideHCID 178505742HCID 178505742, compound

Product 1

HCID 178505747HCID 178505747, compound

Procedure

The title compound was prepared from trans 1-[4-(4-fluorophenyl)-1-cyclohexyl]piperazine and 2-chlorobenzyl chloride by the method described in example 15 to give the product (44%, mp: 83°-85° C.). Calc'd for C23H28ClFN2.0.4H2O: C, 70.09%; H, 7.37%; N, 7.11%. Found: C, 69.99%; H, 7.38%; N, 7.07%.

Sources & evidence

ORD record
ord-ca99ae06f21f499ca7a1d453412059f8
Source dataset
uspto-grants-1997_01
Patent number
US05595993

Reaction notes

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