2-(Bromomethyl)-1,4-difluorobenzene → HCID 178505748, compound

HRID 234630Notes

Reaction equation

HRID 234630 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][CH2:12][C@H:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[F:20][C:21]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:22]=1[CH2:23]Br>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:9][CH2:10][C@H:11]([N:14]3[CH2:15][CH2:16][N:17]([CH2:23][C:22]4[CH:25]=[C:26]([F:29])[CH:27]=[CH:28][C:21]=4[F:20])[CH2:18][CH2:19]3)[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 5228302-(Bromomethyl)-1,4-difluorobenzeneHCID 178505742HCID 178505742, compound

Product 1

HCID 178505748HCID 178505748, compound

Procedure

The title compound was prepared from trans 1-[4-(4-fluorophenyl)-1-cyclohexyl]piperazine and 2,5-difluorobenzyl bromide by the method described in example 15 to give the product (69%, mp: 85°-86° C.). Calc'd for C23H27F3N2 : C, 71.12%; H, 7.01%; N, 7.22%. Found: C, 71.11%; H, 7.01%; N, 7.19%.

Sources & evidence

ORD record
ord-2ae1e42d8e9f4207a5ab5ddd03c0ff31
Source dataset
uspto-grants-1997_01
Patent number
US05595993

Reaction notes

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