AGN-PC-0ND25R → HCID 178505807, compound

HRID 234634Notes

Reaction equation

HRID 234634 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]3[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1.[F:17][C:18]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:19]=1[CH2:20][CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C@H:10]3[CH2:15][CH2:14][C@H:13]([N:24]4[CH2:23][CH2:22][CH:21]([CH2:20][C:19]5[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:18]=5[F:17])[CH2:26][CH2:25]4)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 10932904AGN-PC-0ND25RHCID 233550784-[(2,5-Difluorophenyl)methyl]piperidine

Product 1

HCID 178505807HCID 178505807, compoundYield 31%

Procedure

4-(1,3-Benzodioxol-5-yl)cyclohexanone and 4-(2,5-difluorobenzyl)piperidine were reacted as described in example 9 to give the product (31%, mp: 96°-97° C.). Calc'd for C25H29F2NO2 : C, 72.61%; H, 7.07%; N, 3.39%. Found: C, 72.66%; H, 7.07%; N, 3.30%.

Sources & evidence

ORD record
ord-7c41b6f698d646c6865443701ad9dcd1
Source dataset
uspto-grants-1997_01
Patent number
US05595993

Reaction notes

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