4-(4-Fluorophenyl)cyclohexan-1-one → HCID 178505740, compound

HRID 234635Notes

Reaction equation

HRID 234635 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[F:15][C:16]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:17]=1[CH2:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][CH2:12][C@H:11]([N:22]3[CH2:21][CH2:20][CH:19]([CH2:18][C:17]4[CH:25]=[C:26]([F:29])[CH:27]=[CH:28][C:16]=4[F:15])[CH2:24][CH2:23]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 128343224-(4-Fluorophenyl)cyclohexan-1-oneHCID 233550784-[(2,5-Difluorophenyl)methyl]piperidine

Product 1

HCID 178505740HCID 178505740, compoundYield 36%

Procedure

4-(4-Fluorophenyl)cyclohexanone and 4-(2,5-difluorobenzyl)piperidine were reacted as described in example 9 to give the product (36%, mp: 80°-81° C.). Calc'd for C24H28F3N: C, 74.40%; H, 7.29%; N, 3.18%. Found: C, 74.25%; H, 7.29%; N, 3.56%.

Sources & evidence

ORD record
ord-e0316d510b6642109e8df923cf49344c
Source dataset
uspto-grants-1997_01
Patent number
US05595993

Reaction notes

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