Hydroxylamine HCl → HCID 15279356, compound

HRID 234640Notes

Reaction equation

HRID 234640 reaction equation
[C:1]1(=O)[CH2:6][CH2:5][CH:4]([O:7][C:8]2[C:17]3[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=3[N:11]=[CH:10][N:9]=2)[CH2:3][CH2:2]1.C([O-])(=O)C.[Na+].[Cl-].[OH:25][NH3+:26]>C(O)C>[OH:25][N:26]=[C:1]1[CH2:6][CH2:5][CH:4]([O:7][C:8]2[C:17]3[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=3[N:11]=[CH:10][N:9]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 21645Hydroxylamine HClHCID 517045Sodium AcetateHCID 15279355HCID 15279355, compound

Product 1

HCID 15279356HCID 15279356, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3.8 g (15.5 mmol) of 4-(cyclohexanone-4-oxy)-5,6,7,8-tetrahydroquinazoline in 50 ml of distilled ethanol is first treated with 2.9 g (34.2 mmol) of sodium acetate and then with 2.2 g (31.0 mmol) of hydroxyl ammonium chloride. The reaction mixture is refluxed for 4 hours, and the crystallized product (1.8 g) is subsequently removed by filtration with suction.

Workup

  1. temperatureThe reaction mixture is refluxed for 4 hours
  2. customthe crystallized product (1.8 g) is subsequently removed by filtration with suction

Sources & evidence

ORD record
ord-f7986bbb9ca7444fad7646e92bbad848
Source dataset
uspto-grants-1997_01
Patent number
US05595992

Reaction notes

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