反应详情

5.5 g of Z-Pal-OMe (18.2 mMol) are dissolved in 100 ml of acetonitrile, mixed with 20 ml of 1N NaOH and stirred for 3 hours at ambient temperature. The mixture is neutralised by adding 20 ml of 1N NaOH, the solvent is largely removed on the rotary evaporator and the solid residue is mixed with ice cold water. After suction filtering the mixture is washed with a little water and the residue is dried in the desiccator whereby Z-Pal-OH is obtained in the form of white crystals. M.p.: 82° C.; [α]D20 (MeOH)=-9.4°.

1. customthe solvent is largely removed on the rotary evaporator
2. additionthe solid residue is mixed with ice cold water
3. filtrationAfter suction filtering the mixture
4. washis washed with a little water
5. dry with materialthe residue is dried in the desiccator whereby Z-Pal-OH
6. customis obtained in the form of white crystals