Methanol → Fexofenadine

HRID 2346770Notes

Reaction equation

HRID 2346770 reaction equation
[BH4-:38].[CH3:40][OH:41].[Na+:39].[OH:1][C:2]([CH:3]1[CH2:4][CH2:5][N:6]([CH2:9][CH2:10][CH2:11][C:12](=[O:13])[c:14]2[cH:15][cH:16][c:17]([C:20]([C:21](=[O:22])[OH:23])([CH3:24])[CH3:25])[cH:18][cH:19]2)[CH2:7][CH2:8]1)([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1>>[OH:1][C:2]([CH:3]1[CH2:4][CH2:5][N:6]([CH2:9][CH2:10][CH2:11][CH:12]([OH:13])[c:14]2[cH:15][cH:16][c:17]([C:20]([C:21](=[O:22])[OH:23])([CH3:24])[CH3:25])[cH:18][cH:19]2)[CH2:7][CH2:8]1)([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 28123BorohydrideHCID 99356992-(4-(4-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoic acid

Product 1

HCID 3348Fexofenadine

Sources & evidence

ORD record
ord-980bad08dce14326b9bc5cb43edfd17a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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