Methanol → 2-Chloro-4-morpholin-4-yl-6-(4-morpholin-4-yl-piperidin-1-ylmethyl)-thieno[3,2-d]pyrimidine

HRID 2346829Notes

Reaction equation

HRID 2346829 reaction equation
[C:31]([O:32][BH-:33]([O:34][C:35](=[O:36])[CH3:37])[O:38][C:39](=[O:40])[CH3:41])(=[O:42])[CH3:43].[CH3:44][OH:45].[Cl:1][c:2]1[n:3][c:4]([N:13]2[CH2:14][CH2:15][O:16][CH2:17][CH2:18]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH:11]=[O:12])[s:10]2.[NH:19]1[CH2:20][CH2:21][CH:22]([N:25]2[CH2:26][CH2:27][O:28][CH2:29][CH2:30]2)[CH2:23][CH2:24]1>>[Cl:1][c:2]1[n:3][c:4]([N:13]2[CH2:14][CH2:15][O:16][CH2:17][CH2:18]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:19]1[CH2:20][CH2:21][CH:22]([N:25]3[CH2:26][CH2:27][O:28][CH2:29][CH2:30]3)[CH2:23][CH2:24]1)[s:10]2

Participants

5

Reactant 4

HCID 887MethanolHCID 7957244-MorpholinopiperidineHCID 2724942TriacetoxyborohydrideHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 574939772-Chloro-4-morpholin-4-yl-6-(4-morpholin-4-yl-piperidin-1-ylmethyl)-thieno[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-d32503c511954969a34c1ab0a01c0da0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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