Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (7-Chloro-quinolin-4-yl)-(3-piperidin-1-yl-propyl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4,7-Dichloroquinoline | HCID 6866 | — |
| 반응물 | Piperidine-1-propylamine | HCID 19049 | — |
| 반응물 | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (7-Chloro-quinolin-4-yl)-(3-piperidin-1-yl-propyl)-amine | HCID 10913722 | — |
반응 단계
2.73 g from 2.83 g of 3-(piperidin-1-yl)-propylamine and 3.94 g of 4,7-dichloroquinoline (reaction duration, 16 hours at 140° C.); the base (yellowish crystals from acetonitrile, m.p.: 113°-116° C.) was converted with isopropanolic hydrochloric acid into the dihydrochloride which when recrystallized from acetonitrile/ethanol, yielded colourless crystals, m.p.: 137°-141° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05596002 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-30c5f25c52664d9c892ac049451b9f1a |
| 출처 메모 | uspto-grants-1997_01 |