Methanol → HCID 11601368, compound

HRID 234695Notes

Reaction equation

HRID 234695 reaction equation
Cl.[Cl:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([NH:13][CH2:14][C@H:15]([N:17]([CH3:19])[CH3:18])C)=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.[CH3:20]O>>[Cl:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([NH:13][C@H:14]([CH3:20])[CH2:15][N:17]([CH3:18])[CH3:19])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 86750221HCID 86750221, compound

Product 1

HCID 11601368HCID 11601368, compound

Procedure

Analogously to Example 33c, starting from (R)-2-amino-1-chloro-N-(7-chloro-quinolin-4-yl)-propane hydrochloride there is prepared (R)-N1 -(7-chloro-quinolin-4-yl)-N2,N2 -dimethyl-propane-1,2-diamine hydrochloride; white crystals; m.p.: >260° C., [a]D =-132° (c=1.0, MeOH).

Sources & evidence

ORD record
ord-19b4276bf9d542ccaf843257680e607f
Source dataset
uspto-grants-1997_01
Patent number
US05596002

Reaction notes

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