HCID 55290185, compound → HCID 11507234, compound

HRID 234696Notes

Reaction equation

HRID 234696 reaction equation
Cl.CN(C)[C@H](C)CN.Cl.[Cl:10][C:11]1[CH:20]=[C:19]2[C:14]([C:15]([NH:21][CH2:22][C@H:23]([N:25]([CH3:27])[CH3:26])[CH3:24])=[CH:16][CH:17]=[N:18]2)=[CH:13][CH:12]=1>CO>[Cl:10][C:11]1[CH:20]=[C:19]2[C:14]([C:15]([NH:21][CH2:22][C@H:23]([N:25]([CH3:26])[CH3:27])[CH3:24])=[CH:16][CH:17]=[N:18]2)=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 55290185HCID 55290185, compoundHCID 86750221HCID 86750221, compound

Product 1

HCID 11507234HCID 11507234, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Analogous to Example 33g, starting from (R)-N2,N2 -dimethyl-1,2-propanediamine hydrochloride, we prepared (R)-N1 -(7-chloro-quinolin-4-yl)-N2,N2 -dimethyl-propane-1,2-diamine hydrochloride; white crystals, m.p.: 250° C., [a]D =-9.4° (c=1.0, MeOH).

Sources & evidence

ORD record
ord-df466f70f4ad4db083aac7c7e05018d5
Source dataset
uspto-grants-1997_01
Patent number
US05596002

Reaction notes

Loading…