HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → Toluene-4-thiosulfonic acid S-(2-amino-5-tert-butyl-benzothiazol-6-yl)ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Carbon Tetrachloride | HCID 5943 | — |
| Reactant | 4-Methylbenzene-1-sulfonyl bromide | HCID 10130885 | — |
| Reactant | 2-Amino-5-tert-butyl-benzothiazole-6-thiol | HCID 22572893 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Toluene-4-thiosulfonic acid S-(2-amino-5-tert-butyl-benzothiazol-6-yl)ester | HCID 54107741 | — |
Reaction Steps
The title compound was prepared according to General Method 15 using 2-amino-5-tert-butyl-benzothiazole-6-thiol (7.0 g, 29 mmol), pyridine (2.3 g, 29 mmol), tosyl bromide (6.9 g, 29 mmol), carbon tetrachloride (100 mL), and EtOAc (100 mL). The crude reaction mixture was purified by flash chromatography (5% EtOAc in hexanes to 50% EtOAc in hexanes as eluents). MS(APCI): 393 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06852711B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-744acca6c2e34783b67449eea5838420 |
| Source note | uspto-grants-2005_02 |