Sulfuric Acid → tert-Butyl (R)-2-hydroxybutyrate

HRID 234794Notes

Reaction equation

OS(O)(=O)=O.[C:6]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])(=[O:11])[CH2:7][C:8]([CH3:10])=[O:9].Cl>>[OH:9][C@H:8]([CH3:10])[CH2:7][C:6]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 88290588HCID 88290588, compound

Product 1

HCID 9898902tert-Butyl (R)-2-hydroxybutyrate

Procedure

Following the procedure described in Example 3 with the exception that 2N H2SO4 was substituted for the 2N HCl tert-butyl acetoacetate was reduced to the titled product.

Sources & evidence

ORD record: ord-9cadf0ae6c3a438486cc00b841aa1507
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05596113

Reaction notes

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