反应详情

6-tert-Butyl-5-thiocyanato-2,3-dihydro-1H-indole (prepared in Example JJ; 4.5 g, 19 mmol) was taken in CH2Cl2 (50 mL) and treated with 4-cyanophenylsulfonyl chloride (3.91 g, 19.4 mmol) and pyridine (5 mL). The reaction mixture was stirred overnight, quenched with saturated NaHCO3 solution, and diluted with EtOAc. The organic layer was separated, dried (MgSO4), and concentrated. The crude product was purified by flash chromatography (20%-75% EtOAc in hexanes as eluents). MS(APCI): 397 (M+).

1. customquenched with saturated NaHCO3 solution
2. additiondiluted with EtOAc
3. customThe organic layer was separated
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customThe crude product was purified by flash chromatography (20%-75% EtOAc in hexanes as eluents)