HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl-(E)-4-(2'-fluoro-5'-chlorophenyl)-4-oxo-butenoate → Methyl 4-(2'-fluoro-5'-chlorobenzoyl)-5-hydroxynicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl-(E)-4-(2'-fluoro-5'-chlorophenyl)-4-oxo-butenoate | HCID 10562170 | — |
| Reactant | 5-Ethoxyoxazole-2-carboxylic acid | HCID 12435504 | — |
| Product | Methyl 4-(2'-fluoro-5'-chlorobenzoyl)-5-hydroxynicotinate | HCID 10710045 | — |
Reaction Steps
Diels-Alder reaction of intermediate (XX) with the known 5-ethoxyoxazole-2-carboxylic acid (XXI) (step w) to give methyl 5-hydroxy-4-(2'-fluoro-5'-chlorobenzoyl)nicotinate (XXII);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05596097 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-5ccf716adbd0451eab6f08d1bbf3e88c |
| Source note | uspto-grants-1997_01 |