HCID 23224149, compound → HCID 23355558, compound

HRID 234812Notes

Reaction equation

HRID 234812 reaction equation
FC1C2C(=O)C3C=CN=CC=3C(=O)C=2C(O)=CC=1.[Cl:19][C:20]1[C:25]2[C:26](=[O:35])[C:27]3[CH:28]=[CH:29][N:30]=[CH:31][C:32]=3[C:33](=[O:34])[C:24]=2[C:23]([OH:36])=[CH:22][CH:21]=1.FC1C2C(=O)C3C=CN=CC=3C(=O)C=2C([O:54][S:55]([C:58]2[CH:63]=[CH:62][C:61]([CH3:64])=[CH:60][CH:59]=2)(=O)=[O:56])=CC=1>C(Cl)Cl>[Cl:19][C:20]1[C:25]2[C:26](=[O:35])[C:27]3[CH:28]=[CH:29][N:30]=[CH:31][C:32]=3[C:33](=[O:34])[C:24]=2[C:23]([O:36][S:55]([C:58]2[CH:63]=[CH:62][C:61]([CH3:64])=[CH:60][CH:59]=2)(=[O:56])=[O:54])=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 23224149HCID 23224149, compoundHCID 23355550HCID 23355550, compoundHCID 23355554HCID 23355554, compound

Product 1

HCID 23355558HCID 23355558, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the procedure of Preparative Example 15 and using the mixture of 6-fluoro-9-hydroxybenzo[g]isoquinoline-5,10-dione and 6-chloro-9-hydroxybenzo [g]isoquinoline-5,10-dione obtained in Preparative Example 16 as starting material, an approximately 60/40 mixture of 6-fluoro-9-(p-toluenesulfonyloxy)benzo [g]isoquinoline-5,10-dione and 6-chloro-9-(p-toluenesulfonyloxy)benzo[g]isoquinoline-5,10-dione is obtained as a yellow powder, m.p. 193°-195° C. (from methylene chloride).

Workup

  1. customobtained in Preparative Example 16

Sources & evidence

ORD record
ord-6b0391a358a54b4f8634a55a573eb817
Source dataset
uspto-grants-1997_01
Patent number
US05596097

Reaction notes

Loading…