Hydrochloric Acid → 4-(2'-Fluoro-5'-chlorobenzoyl)-5-hydroxynicotinic acid

Participants

Reaction Steps

Methyl 4-(2'-fluoro-5'-chlorobenzoyl)-5-hydroxynicotinate of Preparative Example 25 (1.2 g) is added to a solution of sodium hydroxide (0.67 g) in water (4 mL) and methanol (12 mL). A yellow solution is obtained after 5 min. The mixture is stirred at room temperature for 1.25 h. The resulting solution is acidified with 1N hydrochloric acid (14 mL) to pH=2 and the mixture is allowed to stand overnight. The white solid is collected by filtration and washed with water (3×5 mL) and dried to yield 4-(2'-fluoro-5'-chlorobenzoyl)-5-hydroxynicotinic acid (1.04 g).

Provenance & Evidence