Toluene → Tert-butyl 2-(4-phenylthiophen-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

HRID 2348238Notes

Reaction equation

HRID 2348238 reaction equation
[Br:16][c:17]1[s:18][cH:19][c:20](-[c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[cH:21]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]2[CH2:11][NH:12][CH2:13][CH:14]2[CH2:15]1.[CH3:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1.[O:37]=[C:38]([CH:39]=[CH:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1)[CH:47]=[CH:48][c:49]1[cH:50][cH:51][cH:52][cH:53][cH:54]1.[O:55]=[C:56]([CH:57]=[CH:58][c:59]1[cH:60][cH:61][cH:62][cH:63][cH:64]1)[CH:65]=[CH:66][c:67]1[cH:68][cH:69][cH:70][cH:71][cH:72]1.[O:73]=[C:74]([CH:75]=[CH:76][c:77]1[cH:78][cH:79][cH:80][cH:81][cH:82]1)[CH:83]=[CH:84][c:85]1[cH:86][cH:87][cH:88][cH:89][cH:90]1.[Pd:35].[Pd:36]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]2[CH2:11][N:12]([c:17]3[s:18][cH:19][c:20](-[c:22]4[cH:23][cH:24][cH:25][cH:26][cH:27]4)[cH:21]3)[CH2:13][CH:14]2[CH2:15]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 23938Palladium2×HCID 95417Dibenzylidene acetone3×HCID 9014662-Bromo-4-phenylthiopheneHCID 4142526Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate

Product 1

HCID 66846446Tert-butyl 2-(4-phenylthiophen-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

Sources & evidence

ORD record
ord-d71d45a605e74d0d81b08437482fd3e3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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