Dichloromethane → HCID 86750235, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(carboxymethoxy)-5-[(2-chloro -α,α,α-trifluoro-p-tolyl)oxy]benzoic acid (16.0 g, 40.95 mmol) in methylene chloride is cooled to -8° C., treated with oxalyl chloride (20.8 g, 163.8 mmol) and four drops of N,N-dimethylformamide, stirred for several minutes and concentrated in vacuo to obtain a solid. The solid is dissolved in toluene and the resultant organic solution is concentrated in vacuo to give the title product as an off-white solid (16.7 g, 95.4%).

Provenance & Evidence