2-(Trifluoromethyl)benzeneboronic acid → 3-Hydroxy-1-[6-(2-trifluoromethyl-phenyl)-pyridin-3-ylmethyl]-1H-thieno[3,2-d]pyrimidine-2,4-dione

HRID 2348487Notes

Reaction equation

HRID 2348487 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][n:9]2[c:10](=[O:20])[n:11]([OH:19])[c:12](=[O:18])[c:13]3[c:14]2[cH:15][cH:16][s:17]3)[cH:6][n:7]1.[F:21][C:22]([c:23]1[c:24]([B:29]([OH:30])[OH:31])[cH:25][cH:26][cH:27][cH:28]1)([F:32])[F:33]>>[c:2]1(-[c:24]2[c:23]([C:22]([F:21])([F:32])[F:33])[cH:28][cH:27][cH:26][cH:25]2)[cH:3][cH:4][c:5]([CH2:8][n:9]2[c:10](=[O:20])[n:11]([OH:19])[c:12](=[O:18])[c:13]3[c:14]2[cH:15][cH:16][s:17]3)[cH:6][n:7]1

Participants

3

Reactant 2

HCID 27343872-(Trifluoromethyl)benzeneboronic acidHCID 116667261-(6-chloro-pyridin-3-ylmethyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dione

Product 1

HCID 115026263-Hydroxy-1-[6-(2-trifluoromethyl-phenyl)-pyridin-3-ylmethyl]-1H-thieno[3,2-d]pyrimidine-2,4-dione

Sources & evidence

ORD record
ord-817a0dc581ed4d53b9df8a497d0b70e9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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