HCID 23353100, compound → HCID 136087735, compound

HRID 234870Notes

Reaction equation

HRID 234870 reaction equation
[C:1]([CH:5]1[C:10](=[O:11])[CH2:9][CH:8]([CH:12]2[CH2:17][CH2:16][CH2:15][S:14][CH2:13]2)[CH2:7][C:6]1=[O:18])(=O)[CH2:2][CH3:3].[Br:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]=[CH:27][CH2:28][O:29][NH2:30])=[CH:22][CH:21]=1>CO>[Br:19][C:20]1[CH:21]=[CH:22][C:23]([CH:26]=[CH:27][CH2:28][O:29][N:30]=[C:1]([C:5]2[C:10](=[O:11])[CH2:9][CH:8]([CH:12]3[CH2:17][CH2:16][CH2:15][S:14][CH2:13]3)[CH2:7][C:6]=2[OH:18])[CH2:2][CH3:3])=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 23353100HCID 23353100, compoundHCID 54468234HCID 54468234, compound

Product 1

HCID 136087735HCID 136087735, compoundYield 68.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.0 g (0.011 mol) of 2-propionyl-5-(3-tetrahydrothiopyranyl)-cyclohexane-1,3-dion and 3.0 g (0.013 mol) of 3-(4-bromophenyl)-prop-2-enyloxiamine in 100 ml of methanol were stirred at 20° C. for 16 hours. The precipitated reaction product was isolated at 0° C. washed with ice-cold methanol and petroleum ether and dried. Yield 68.4%; m.p.: 97°-99° C.

Workup

  1. customThe precipitated reaction product
  2. customwas isolated at 0° C.
  3. washwashed with ice-cold methanol and petroleum ether
  4. customdried

Sources & evidence

ORD record
ord-9a7df26f1b734cd586d405b1a6d7c4e1
Source dataset
uspto-grants-1997_01
Patent number
US05597776

Reaction notes

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