Ethyl cyanoacetate → HCID 178432555, compound

Participants

Reaction Steps

A suspension of 3 g (22 mmol) of 4-amino-5-formyl-3-methylpyrimidine, 5 g (44 mmol) of ethylcyanoacetate and 850 mg (100 mmol) of piperidine in 20 ml of ethanol was stirred for 20 hours at 20°-25° C. The fine-particled solid formed was separated off, freed from solvent residues under reduced pressure and suspended twice in 20 ml of ethanol each time. The crude product was finally washed with diethyl ether. Yield: 50% (fine powder); mp.: >200° C.

Provenance & Evidence