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Water → methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Chloropropionyl chloride | HCID 111019 | — |
| 反応物 | Benzoic acid, 4-amino-3-hydroxy-, methyl ester | HCID 7020619 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate | HCID 10798997 | 70.8% |
反応手順
To a solution of 2-amino-5-methoxycarbonylphenol [Tetrahedron, 46(15), 5177-5186 (1990)] (8.3 g) in dimethylformamide (65 ml) were added potassium carbonate (20.5 g) and 2-chloropropionyl chloride (6.9 g) and the mixture was stirred at room temperature for a day. The reaction solution was poured into water to give precipitates, which were taken by filtration and dried to give 7-methoxycarbonyl-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (7.78 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05597820 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-68d0c4cad0734286911db16b91363e0c |
| 出典メモ | uspto-grants-1997_01 |