1-cyclopropyl-4-iodopyridin-2(1H)-one → 3-[1-[4-(1-Cyclopropyl-2-oxo-4-pyridinyl)phenyl]ethyl]-6-(2-fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-1,3-oxazinan-2-one

HRID 2348904Notes

Reaction equation

HRID 2348904 reaction equation
[CH:37]1([n:40]2[c:41](=[O:47])[cH:42][c:43]([I:46])[cH:44][cH:45]2)[CH2:38][CH2:39]1.[F:1][c:2]1[c:3]([C:8]2([CH2:32][C:33]([CH3:34])([CH3:35])[OH:36])[CH2:9][CH2:10][N:11]([CH:15]([CH3:16])[c:17]3[cH:18][cH:19][c:20]([B:23]4[O:24][C:25]([CH3:26])([CH3:27])[C:28]([CH3:29])([CH3:30])[O:31]4)[cH:21][cH:22]3)[C:12](=[O:14])[O:13]2)[cH:4][cH:5][cH:6][cH:7]1>>[F:1][c:2]1[c:3]([C:8]2([CH2:32][C:33]([CH3:34])([CH3:35])[OH:36])[CH2:9][CH2:10][N:11]([CH:15]([CH3:16])[c:17]3[cH:18][cH:19][c:20](-[c:43]4[cH:42][c:41](=[O:47])[n:40]([CH:37]5[CH2:38][CH2:39]5)[cH:45][cH:44]4)[cH:21][cH:22]3)[C:12](=[O:14])[O:13]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 591903761-cyclopropyl-4-iodopyridin-2(1H)-oneHCID 723444326-(2-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]-1,3-oxazinan-2-one

Product 1

HCID 750924213-[1-[4-(1-Cyclopropyl-2-oxo-4-pyridinyl)phenyl]ethyl]-6-(2-fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-1,3-oxazinan-2-one

Sources & evidence

ORD record
ord-81ffab0b83824ac898f663b870c47350
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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