HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzoic acid, 4-amino-3-hydroxy-, methyl ester | HCID 7020619 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate | HCID 10845978 | 73.3% |
Reaction Steps
To a solution of 2 -amino-5 -methoxycarbonylphenol [Tetrahedron, 46(15), 5177-5186 (1990)] (2.20 g) in dimethylformamide (30 ml) were added potassium carbonate (4.00 g) and 2-chloroacetyl chloride (1.50 g) and the mixture was stirred at room temperature for 1 hour. The reaction solution was poured into water to give precipitates, which were taken by filtration and dried to give 7-methoxycarbonyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (2.00 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05597820 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-3758bf8c21ed4d23b8bb6d4868a63226 |
| Source note | uspto-grants-1997_01 |