Ammonia → 2,4-Diamino-5-(2,4-dichlorophenyl)-6-methylthiopyrimidine

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-	HCID 112414	—
Reactant	2-Amino-4-chloro-5-(2,4-dichlorophenyl)-6-methylthio pyrimidine	HCID 19705079	—
Catalyst	Copper	HCID 23978	—
Solvent	Ethanol	HCID 702	—
Product	2,4-Diamino-5-(2,4-dichlorophenyl)-6-methylthiopyrimidine	HCID 19705117	1,181.2%

Reaction Conditions

Temperature	180 °C

Reaction Steps

A mixture of 2-amino-4-chloro-5-(2,4-dichlorophenyl)-6-methylthio pyrimidine (0.5 g) (Example 32) EtOH saturated with ammonia (20 ml), copper powder (0.05 g) and tris[2-(2-methoxyethoxy)ethyl]amine (0.01 g) was heated in an autoclave at 180° C. for 18 hours. The cooled reaction mixture was filtered, evaporated and the residue purified by flash column chromatography to give the title compound (0.11 g, 23.5%), mp. 191°-192° C. Microanalysis:

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05597827
Source dataset	uspto-grants-1997_01
ORD ID	ord-9d85c620209348b58412b91bdcc5e99b
Source note	uspto-grants-1997_01