Sodium Hydroxide → HCID 19705068, compound

HRID 234949Notes

Reaction equation

HRID 234949 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])=[C:4]([CH3:16])[N:3]=1.[N+:17]([O-])([O-:19])=[O:18].[K+].[OH-].[Na+]>OS(O)(=O)=O>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=[CH:11][C:10]=2[Cl:15])=[C:4]([CH3:16])[N:3]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24434Potassium NitrateHCID 19705069HCID 19705069, compound

Product 1

HCID 19705068HCID 19705068, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To a solution of 2,4-diamino-5-(2-chlorophenyl)-6-methyl pyrimidine (11.84 g) (Example 22) in concentrated H2SO4 (100 ml), was added potassium nitrate (5.1 g). After stirring at room temperature for 90 minutes, the solution was poured onto ice and basified with 10N NaOH. The product was extracted with ethyl acetate, bulked, dried (MgSO4) and evaporated, 13.9 g, 236°-240° C.

Workup

  1. extractionThe product was extracted with ethyl acetate
  2. dry with materialdried (MgSO4)
  3. customevaporated
  4. custom13.9 g, 236°-240° C.

Sources & evidence

ORD record
ord-c9e5f156873d407d89cdc10c3649f377
Source dataset
uspto-grants-1997_01
Patent number
US05597827

Reaction notes

Loading…