Morpholine → 5-Morpholin-4-yl-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([C:18]([F:19])([F:20])[F:21])[c:13]([I:17])[cH:14][c:15]2[CH2:16]1.[CH2:22]1[CH2:23][O:24][CH2:25][CH2:26][NH:27]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([C:18]([F:19])([F:20])[F:21])[c:13]([N:27]3[CH2:22][CH2:23][O:24][CH2:25][CH2:26]3)[cH:14][c:15]2[CH2:16]1Participants
3
Sources & evidence
- ORD record
- ord-81ed7dfa89d04f0e9be7cd3b2f528358
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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