Dimethylamine → 2,4-Diamino-5-(2,4-dichlorophenyl)-6-dimethylaminomethylpyrimidine

HRID 234955Notes

Reaction equation

HRID 234955 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])=[C:4]([CH2:17]Br)[N:3]=1.[CH3:19][NH:20][CH3:21]>C(O)C>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])=[C:4]([CH2:17][N:20]([CH3:21])[CH3:19])[N:3]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19705067HCID 19705067, compound

Product 1

HCID 197051102,4-Diamino-5-(2,4-dichlorophenyl)-6-dimethylaminomethylpyrimidine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared from 2,4-diamino-5-(2,4-dichlorophenyl)-6-bromomethyl-pyrimidine (Example 53) by reaction with dimethylamine in ethanol at room temperature, mp. 170°-172° C.

Sources & evidence

ORD record
ord-99d1da42d52b4aaaaff8bdff45745867
Source dataset
uspto-grants-1997_01
Patent number
US05597827

Reaction notes

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