HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(Carboxymethyloxy)-4'-cyano-biphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl [(4'-cyanobiphenyl-4-yl)oxy]acetate | HCID 640094 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Carboxymethyloxy)-4'-cyano-biphenyl | HCID 43243100 | — |
Reaction Steps
32.9 g of 4-(tert.butyloxycarbonylmethyloxy)-4'-cyano-biphenyl dissolved in 250 ml of methylene chloride is mixed slowly with 137 ml of trifluoroacetic acid. After stirring for 3 hours, the reaction mixture is evaporated to dryness and the solid residue is triturated with water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05597825 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-2647d34b6ed04ee28679791fce90860a |
| Source note | uspto-grants-1997_01 |