反应详情

温度

125 °C

To 2-amino-4-chloro-5-(2,3-dichlorophenyl)pyrimidine (6.73 gms) was added ethanolic ammonia (30 equiv. in 50 ml EtOH) and the mixture sealed in a Parr reaction vessel and heated to 125° C. for 38 hours. After cooling, the mixture was concentrated in: vacuo and the residue mixed with 1N NaOH (75 ml), filtered, washes with water and dried in vacuo, 6.14 gms, mp. 208°-211° C.

1. customthe mixture sealed in a Parr reaction vessel
2. temperatureAfter cooling
3. concentrationthe mixture was concentrated in: vacuo
4. additionthe residue mixed with 1N NaOH (75 ml)
5. filtrationfiltered
6. dry with materialwashes with water and dried in vacuo, 6.14 gms, mp. 208°-211° C.