Ammonia → 2,4-Diamino-5-(2,3-dichlorophenyl)pyrimidine

HRID 234998Notes

Reaction equation

HRID 234998 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:10]=2[Cl:16])=[CH:4][N:3]=1.[NH3:17]>>[NH2:1][C:2]1[N:7]=[C:6]([NH2:17])[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:10]=2[Cl:16])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 197050822-Amino-4-chloro-5-(2,3-dichlorophenyl)pyrimidine

Product 1

HCID 197050772,4-Diamino-5-(2,3-dichlorophenyl)pyrimidine

Conditions

Temperature
125 °C

Procedure

To 2-amino-4-chloro-5-(2,3-dichlorophenyl)pyrimidine (6.73 gms) was added ethanolic ammonia (30 equiv. in 50 ml EtOH) and the mixture sealed in a Parr reaction vessel and heated to 125° C. for 38 hours. After cooling, the mixture was concentrated in: vacuo and the residue mixed with 1N NaOH (75 ml), filtered, washes with water and dried in vacuo, 6.14 gms, mp. 208°-211° C.

Workup

  1. customthe mixture sealed in a Parr reaction vessel
  2. temperatureAfter cooling
  3. concentrationthe mixture was concentrated in: vacuo
  4. additionthe residue mixed with 1N NaOH (75 ml)
  5. filtrationfiltered
  6. dry with materialwashes with water and dried in vacuo, 6.14 gms, mp. 208°-211° C.

Sources & evidence

ORD record
ord-db63a4422e594ab8874e2f1c29d581ae
Source dataset
uspto-grants-1997_01
Patent number
US05597828

Reaction notes

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