2,5-Dichlorobenzylic alcohol → 2,4-Diamino-5-(2,5-dichlorophenyl)-6-methylpyrimidine

HRID 235009Notes

Reaction equation

HRID 235009 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11](Cl)[C:10]=2[Cl:17])=[C:4]([CH3:18])[N:3]=1.ClC1C=CC(Cl)=CC=1CO>C(Cl)(Cl)Cl.CO>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[Cl:17])=[C:4]([CH3:18])[N:3]=1

Participants

4

Reactant 2

HCID 1186042,5-Dichlorobenzylic alcoholHCID 115512322,4-Diamino-6-methyl-5-(2,3,5-trichlorophenyl)pyrimidine

Product 1

HCID 197051162,4-Diamino-5-(2,5-dichlorophenyl)-6-methylpyrimidine

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

This compound was made in an analogous manner to the compound of Example 6 from 2,5-dichlorobenzylalcohol (Lancaster Synthesis). Mp. 226°-228° C.: TLC (SiO2 : CHCl3 /MeOH, 9.1) Rf=0.24.

Sources & evidence

ORD record
ord-ba39298c5898456a8bde51c3446df9ec
Source dataset
uspto-grants-1997_01
Patent number
US05597828

Reaction notes

Loading…