Dimethyl Sulfide → 3-(N-Methyamino)-2-carboethoxy-benzothiophene

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Reaction Steps

3-Amino-2-carboethoxy-benzothiophene (1.11 g, 5 mmol) was reacted with formic acetic anhydride followed by reduction by BH3.DMS, using the procedure described by Krishmanurthy in Tetrahedron Lett, 23:33 15-8 (1982), to yield 0.59 g of the title compound as a light yellow solid. 1H NMR (300 MHz, CDCl3) δ 1.39 (t, 3H), 3.41 (d, 3H), 4.33 (q, 2H), 7.28 (t, 1H), 7.41 (t, 1H), 7.53 (br s, 1H) (d, 1H), 8.18 (d, 1H).

Provenance & Evidence