Sodium Carbonate → HCID 23353368, compound

Participants

Reaction Steps

4-Chloroisophthalonitrile (5.69 g, 35 mmol), prepared by the method of Markley et al, J. Med. Chem., 29: 427 (1986), was treated with 1 equivalent methyl thioglycolate and 1 equivalent Na2CO3 in methanol by the procedure described in Example 41A to yield the title compound (3.00 g, 37%). m.p. 248° C. 1H NMR (300 MHz, DMSO) δ 8.71 (s, 1H), 8.09 (d, 1H), 7.86 (dd, 1H), 7.30 (br s, 2H), 3.81 (s, 3H). MS (DCI/NH3) m/e 250 (M+NH4)+.

Provenance & Evidence