Ethyl Acetate → HCID 70285636, compound

Participants

Reaction Steps

2-Chloro-3-cyanopyrazine (0.751 g, 5.38 mmol) was treated with methyl glycolate (0.533 g, 5.92 mmol) and potassium carbonate (1.12 g, 8.07 mmol) in 20 ml DMF as described in Example 85A. Column chromatograhpy on silica gel eluting with 1:1 hexanes:ethyl acetate gave the title compound (0.33 g, 32%) as a yellow solid. 1H NMR (300 MHz, CDCl3) δ4.02 (s, 3H), 5.29 (br s, 2H), 8.47 (d, 1H), 8.56 (d, 1H). MS (DCI/NH3) m/e 194 (M+H)+, 211 (M+NH4)+.

Provenance & Evidence