Benzyl Bromide → HCID 23353357, compound

Participants

Reaction Steps

Ethyl 3-aminothieno[2,3-b]pyrazine-2-carboxylate (0.450 g, 2.02 mmol) was treated with neat NaH (0.058 g, 2.42 mmol) and benzyl bromide (0.380 g, 2.22 mmol) as described in Example 94A. Purification by column chromatography on silica gel eluting with a solvent gradient from 10:1 to 3:1 hexanes:ethyl acetate gave the title compound (0.39 g, 62%) as a yellow solid. 1H NMR (300 MHz, CDCl3) δ1.39 (t, 3H), 4.37 (q, 2H), 5.38 (d, 2H), 7.19-7.42 (m, 5H), 7.88 (br t, 1H), 8.55 (m, 2H). MS (DCI/NH3) m/e 3 14 (M+H)+.

Provenance & Evidence