Doxorubicin → HCID 86703813, compound

HRID 2350832Notes

Reaction equation

HRID 2350832 reaction equation
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].[CH3:21][C@@H:22]1[O:27][C@@H:26]([O:28][C@@H:29]2[C:34]3=[C:35]([OH:52])[C:36]4[C:48](=[O:49])[C:47]5[C:42](=[CH:43][CH:44]=[CH:45][C:46]=5[O:50][CH3:51])[C:40](=[O:41])[C:37]=4[C:38]([OH:39])=[C:33]3[CH2:32][C@@:31]([OH:57])([C:53]([CH2:55][OH:56])=[O:54])[CH2:30]2)[CH2:25][C@H:24]([NH2:58])[C@@H:23]1[OH:59]>O.[Na+].[Cl-]>[CH2:6]([C@H:2]([NH2:1])[C:3]([OH:5])=[O:4])[CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9].[CH3:21][C@@H:22]1[O:27][C@@H:26]([O:28][C@@H:29]2[C:34]3=[C:35]([OH:52])[C:36]4[C:48](=[O:49])[C:47]5[C:42](=[CH:43][CH:44]=[CH:45][C:46]=5[O:50][CH3:51])[C:40](=[O:41])[C:37]=4[C:38]([OH:39])=[C:33]3[CH2:32][C@@:31]([OH:57])([C:53]([CH2:55][OH:56])=[O:54])[CH2:30]2)[CH2:25][C@H:24]([NH2:58])[C@@H:23]1[OH:59]

Participants

4

Reactant 2

HCID 31703DoxorubicinHCID 124886Glutathione

Product 1

HCID 86703813HCID 86703813, compound

Reagents, catalysts & solvents 1

HCID 57417360Sodium chloride; waterSolvent2×

Procedure

Six animals were treated i.v. in the morning (10 am.) with glutathione g/kg) dissolved in normal saline (total injected volume 1 ml/kg). After 30 minutes, the same animals were treated i.v. with doxorubicin (3 mg/kg) dissolved in normal saline (total injected volume 1 ml/kg).

Workup

  1. additionSix animals were treated i.v
  2. additionthe same animals were treated i.v

Sources & evidence

ORD record
ord-dd83975a837442399baf689bae8362e1
Source dataset
uspto-grants-1989_10
Patent number
US04871528

Reaction notes

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