HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Aminopiperidine → 2,10-dihydro-10-(1-piperidinyl)imidazo[2,1-b]quinazolin-5(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Aminopiperidine | HCID 16658 | — |
| Reactant | 1-(2-Fluorobenzoyl)-2-methylthio-2-imidazoline | HCID 3236905 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | 2,10-dihydro-10-(1-piperidinyl)imidazo[2,1-b]quinazolin-5(3H)-one | HCID 14387118 | 71% |
Reaction Steps
A solution of 10.0 g (42.0 mmoles) of the product of Example 1 and 25 ml of 1-aminopiperidine in 50 ml of 2-methoxyethyl ether (diglyme) was heated at reflux for 15 hours. The solution as diluted while hot with about 5 ml of water and allowed to cool. The resulting white needles were collected, washed with ethanol, and air-dried to give 8.10 g of 2,10-dihydro-10-(1-piperidinyl)imidazo[2,1-b]quinazolin-5(3H)-one. Melting point 229°-231° C. Total yield 71%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04871732 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-a103d892249649af848becb865255592 |
| Source note | uspto-grants-1989_10 |