1-Pyrrolidinamine → 2,10-Dihydro-10-(1-pyrrolidinyl)imidazo[2,1-b]quinazolin-5(3H)-one

HRID 2350856Notes

Reaction equation

F[C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[C:4]([N:6]1[CH2:10][CH2:9][N:8]=[C:7]1SC)=[O:5].[NH2:17][N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>>[N:18]1([N:17]2[C:2]3[C:3](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:4](=[O:5])[N:6]3[CH2:10][CH2:9][N:8]=[C:7]23)[CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

Reactant 2

HCID 279461-Pyrrolidinamine

HCID 32369051-(2-Fluorobenzoyl)-2-methylthio-2-imidazoline

Product 1

HCID 198473812,10-Dihydro-10-(1-pyrrolidinyl)imidazo[2,1-b]quinazolin-5(3H)-one

Procedure

When the procedure of Example 2 is repeated using the product of Example 1 and N-aminopyrrolidine, the product obtained is 2,10-dihydro-10-(1-pyrrolidinyl)imidazo[2,1-b]quinazolin-4(3H)-one.

Workup

customthe product obtained

Sources & evidence

ORD record: ord-a79e4c0bcf6d48bba92883d4c569f872
Source dataset: uspto-grants-1989_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04871732

Reaction notes

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