HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2350860Generated: October 26, 2026
1-Aminohomopiperidine → 10-(hexahydro-1H-azepin-1yl)-2,10-dihydroimidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one
https://huagongshe.com/reaction/2350860
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Aminohomopiperidine | HCID 22198 | — |
| Reactant | 1-(2-Chloropyridine-3-carbonyl)-2-methylthio-2-imidazoline | HCID 14387135 | — |
| Product | 10-(hexahydro-1H-azepin-1yl)-2,10-dihydroimidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one | HCID 14387138 | 66.3% |
Reaction Steps
A mixture of 10.0 g (39.1 mmoles) of the product of Example 12 and 12.5 g (0.109 mole) of N-aminohomopiperidine was heated at 160° C. for 1 hour. Excess N-aminohomopiperidine was removed by Kugelrohr distillation and the residue was partitioned between methylene chloride and water. The organic layer was dried (sodium sulfate) and concentrated leaving 7.40 g of 10-(hexahydro-1H-azepin-1yl)-2,10-dihydroimidazo[1,2-a]pyrido[2,3-d]pyrimidin-5(3H)-one; melting point 217°-219° C. Total yield 66%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04871732 |
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| Source dataset | uspto-grants-1989_10 |
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| ORD ID | ord-859f62a318fa40cd854cf54ffaa69ebb |
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| Source note | uspto-grants-1989_10 |
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