反应详情

1.12 g of 2-ethylaminobenzyl bromide hydrobromide are added to a solution of 0.60 g of 2-mercaptothieno-[3,4-d]imidazole in 100 ml of acetone. After the mixture has been stirred at room temperature for 24 hours, the solvent is removed by distillation in vacuo, and the crystalline residue is washed with acetone. Then 1N NH4OH solution is added to the product, the mixture is stirred for 2 hours, and the solid is filtered off with suction and washed wit water. The residue which has been dried in air is dissolved in methylene chloride, active charcoal is added, and the mixture is filtered. Concentration in vacuo results in the clorless crystalline product.

1. customthe solvent is removed by distillation in vacuo
2. washthe crystalline residue is washed with acetone
3. additionThen 1N NH4OH solution is added to the product
4. stirringthe mixture is stirred for 2 hours
5. filtrationthe solid is filtered off with suction
6. washwashed wit water
7. customThe residue which has been dried in air
8. dissolutionis dissolved in methylene chloride
9. additionactive charcoal is added
10. filtrationthe mixture is filtered
11. concentrationConcentration in vacuo
12. customresults in the clorless crystalline product