Hydrochloric Acid → HCID 178508747, Verbindung

HRID 2350868Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2350868
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[CH:34]=[CH:33][C:16]([C:17]([NH:19][C@H:20]([C:28]([O:30]CC)=[O:29])[CH2:21][CH2:22][C:23]([O:25]CC)=[O:24])=[O:18])=[CH:15][CH:14]=2)=[C:4]([OH:35])[N:3]=1.Cl>[OH-].[Na+]>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:17]([NH:19][C@H:20]([C:28]([OH:30])=[O:29])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[O:18])=[CH:33][CH:34]=2)=[C:4]([OH:35])[N:3]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 178471570HCID 178471570, Verbindung

Produkt 1

HCID 178508747HCID 178508747, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A mixture of 0.50 g of diethyl N-(4-[4-(2,4-diamino-6-hydroxypyrimidin-5-yl)butyl]benzoyl)-L-glutamate and 40 mL of 1N sodium hydroxide is stirred at room temperature for 72 hours. The mixture is neutralized with hydrochloric acid and the solid which forms is collected by filtration, washed with water and dried to yield N-(4-[4-(2,4-diamino-6-hydroxypyrimidin-5-yl)-butyl]benzoyl)-L-glutamic acid, m.p. 169°-171° C.; IR (KBr) vmax 3340, 3200, 2920, 2860, 1600, 1380, 1170, and 755 cm-1 ; 1H NMR (dTFA) delta 7.30 (d, J=8.7 Hz, 2H, Ar), 6.90 (d, J=8.7 Hz, 2H, Ar), 4.56-4.61 (m, 1H), 2.26-2.38 (m, 4H, 2' aliphatic), 1.93-2.14 (m, 4H, 2° aliphatic), 1.25-1.34 (m, 2H, 2° aliphatic), 1.05-1.17 (m, 2H, 2° aliphatic).

Aufarbeitung

  1. filtrationthe solid which forms is collected by filtration
  2. washwashed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4c9ee2e5986344e29caf163696606655
Quelldatensatz
uspto-grants-1989_10
Patentnummer
US04871743

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