Ethyl 2-chloroacetoacetate → HCID 14500706, compound

Participants

Reaction Steps

A stirred solution of 30.3 g (0.16 mole) of 4-heptyl-3-thiosemicarbazide in 500 mL of absolute ethanol under nitrogen atmosphere was treated with the rapid addition of 26.3 g (0.16 mole) of ethyl 2-chloroacetoacetate, stirred at ambient temperature for ~16 hr, heated at reflux for 3 hr and filtered hot. Concentration of the filtrate in vacuo gave a deep red oil. The oil solidified on standing for ~16 hr and was recrystallized from 2-propyl alcohol to give 15 g of fine white crystals, mp 83°-84° C.

Provenance & Evidence