Sulfuric Acid → HCID 19847677, compound

Participants

Reaction Steps

A solution of 1-(3,5-bistrifluoromethylphenyl)-3-[4-(1,1-dimethyl-2-hydroxyethyl)piperidino]-prop-1-yne (2.0 g) in a mixture of diethyl ether (20 ml) and dichloromethane (5 ml) was treated with a solution of concentrated sulphuric acid in diethyl ether (1:25v/v; 13 ml) with magnetic stirring. After evaporation of the solvent in vacuo, and drying in vacuo at 0.3 mm Hg, 1-(3,5-bistrifluoromethylphenyl)-3-[4-(1,1-dimethyl-2-hydroxyethyl)piperidino]prop-1-yne sulphate (2.4 g) was obtained as a buff semi-solid.

Provenance & Evidence