Nitric Acid → HCID 86743416, compound

Participants

Reaction Steps

A solution of 1-(3,5-bistrifluoromethylphenyl)-3-[4-(1,1-dimethyl-2-hydroxyethyl)piperidino]prop-1-yne (2.0 g) in dry acetone (20 ml) was treated with an aqueous nitric acid solution (0.25M; 19.6 ml) with magnetic stirring. The solvent was evaporated in vacuo, and the residue was dried at 0.3 mm Hg to give 1-(3,5-bistrifluoromethylphenyl)-3-[4-(1,1-dimethyl-2-hydroxyethyl)piperidino]prop-1-yne nitrate (2.28 g) as a brown solid.

Provenance & Evidence