Hydrochloric Acid → HCID 19847672, compound

Participants

Reaction Steps

A solution of 1-(3,5-bistrifluoromethylphenyl)-3-[4-(1,1-dimethyl-2-hydroxyethyl)piperidino]-prop-1-yne (2.0 g) in dry diethyl ether (20 ml) containing a few drops of ethanol, was brought to pH 1 with an ethereal solution of hydrogen chloride gas. The resulting solution was diluted to 40 ml with petroleum ether (b.p. 60°-80° C.), a buff solid was filtered off, washed with a 1:1 solution of diethyl ether and petroleum ether (25 ml), and dried to give 1-(3,5-bistrifluoromethylphenyl)-3-[4-(1,1-dimethyl-2-hydroxyethyl)piperidino]-prop-1yne hydrochloride (2.1 g) m.p 183°-185° C. as buff crystals.

Provenance & Evidence