Acetic Acid → HCID 70377737, compound

4-(1,1-Dimethyl-2-hydroxyethyl)pyridine [which may be prepared as described by Fraenkel et al, J. Amer. Chem. Soc. (1971), 93, 7228; 3 g] was dissolved in acetic acid (30 ml) and hydrogenated in the presence of platinum oxide catalyst for 10 hours at a maximum temperature of 37° C. and a pressure of 50 pounds per square inch, until 100% of the theoretical uptake of hydrogen had occurred. The reaction mixture was then filtered and the filtrate was evaporated under reduced pressure (15 mmHg) to give a pale yellow oil, which was then distilled (b.p. 120° C./0.2 mmHg) to give a colourless oil, which was recrystallised from a mixture of ethanol and diethyl ether to give 4-(1,1-dimethyl-2-hydroxyethyl)piperidine acetate (1.8 g), m.p. 108°-110° C., in the form of colourless crystals.

1. filtrationThe reaction mixture was then filtered
2. customthe filtrate was evaporated under reduced pressure (15 mmHg)
3. customto give a pale yellow oil, which
4. distillationwas then distilled (b.p. 120° C./0.2 mmHg)
5. customto give a colourless oil, which
6. customwas recrystallised from a mixture of ethanol and diethyl ether

ORD record

ord-d63cf5edc0d346a880df4a4fede2cb49

Source dataset

uspto-grants-1989_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04871748